人才队伍
个人简介

北京大学云南白药国际医学研究中心副主任,北京大学药学院教授、博士生导师、副院长,天然药物及仿生药物国家重点实验室副主任。入选国家自然科学基金委杰出青年基金、优秀青年基金、教育部新世纪优秀人才、北京市科技新星等人才计划。

主要研究领域包括:

1. 中药药效成分

1中药化学:中药化学成分的分离纯化、结构鉴定

2中药分析:中药多组分体系的化学成分分析、质量控制、体内代谢、药代动力学

3中药药效:与心血管及代谢性疾病相关的中药活性成分的发现与分子机制

2. 天然产物的生物合成与生物催化

1植物来源重要中药活性成分生物合成关键酶的发现

2糖基转移酶等生物合成酶的催化机制、晶体结构、功能改造。

至今发表SCI论文240余篇,SCI引用7200h指数为46批国家发明专利10项。目前担任J EthnopharmacolJ Pharm Biomed Anal等杂志的副主编或编委,兼任国家药典委员,世界中医药学会联合会中药分析专业委员会副会长,中国植物学会药用植物及植物药专业委员会副主任委员。


代表性学术成果:

1. Meng Zhang, Yang Yi, Baihan Gao, Hui-Fei Su, Yang-Oujie Bao, Xiao-Meng Shi, Hai-Dong Wang, Fu-Dong Li, Min Ye*, Xue Qiao*. Functional characterization and protein engineering of a triterpene 3-/6-/2′-O-glycosyltransferase reveal a conserved residue critical for the regiospecificity. Angew. Chem. Int. Ed. 2022, 61(8), e202113587.

2. Yi Kuang, Bin Li, Zilong Wang, Xue Qiao*, Min Ye*. Terpenoids from the medicinal mushroom Antrodia camphorata: chemistry and medicinal potential. Nat. Prod. Rep. 2021, 38(1), 83-102.

3. Zi-long Wang, Hao-meng Gao, Shuang Wang, Meng Zhang, Kuan Chen, Ya-qun Zhang, Hai-dong Wang, Bo-yun Han, Lu-lu Xu, Tian-qiao Song, Cai-hong Yun, Xue Qiao*, Min Ye*. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc. Natl. Acad. Sci. U. S. A. 2020, 117(48), 30816-30823.

4. Meng Zhang, Fu-dong Li, Kai Li, Zi-long Wang, Yu-xi Wang, Jun-bin He, Hui-fei Su, Zhong-yi Zhang, Chang-biao Chi, Xiao-meng Shi, Cai-hong Yun, Zhi-yong Zhang, Zhen-ming Liu, Liang-ren Zhang, Dong-hui Yang, Ming Ma*, Xue Qiao*, Min Ye*. Functional characterization and structural basis of an efficient di-C-glycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc. 2020, 142(7), 3506-3512.

5. Jun-bin He, Peng Zhao, Zhi-min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-hong Yun*, Xue Qiao*, Min Ye*. Molecular and structural characterization of a promiscuous C-glycosyltransferase from Trollius chinensis. Angew. Chem. Int. Ed. 2019, 58(33), 11513-11520.

6. Kuan Chen, Zhi-min Hu, Wei Song, Zi-long Wang, Jun-bin He, Xiao-meng Shi, Qing-hua Cui, Xue Qiao*, Min Ye*. Diversity of O-glycosyltransferases contributes to the biosynthesis of flavonoid and triterpenoid glycosides in Glycyrrhiza uralensis. ACS Synth. Biol. 2019, 8(8), 1858-1866.

7. Wei Song, Xue Qiao, Kuan Chen, Ying Wang, Shuai Ji, Jin Feng, Kai Li, Yan Lin, Min Ye*. Biosynthesis-based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids. Anal. Chem. 2017, 89(5), 3146-3153.

8. Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu*, Min Ye*. Bioactive constituents of Glycyrrhiza uralensis (licorice): Discovery of the effective components of a traditional herbal medicine. J. Nat. Prod. 2016, 79(2), 281-292.