周德敏，北京大学药学院院长、天然药物与仿生药物国家重点实验室主任；基金委创新群体/国家创新药物重大专项牵头科学家、科技部973首席科学家、“万人计划”科技创新领军人才、教育部长江学者特聘教授；中国药学会药化分会副主任委员、美国化学会Molecular Pharmaceutics副主编。
长期从事基于化学-生物学交叉的新药发现新技术新方法研究，包括抗病毒中药活性物质基础、长效低免疫原性内源性大分子药物、抗体-细胞毒药物定点偶联、靶向低免疫原性AAV病毒载体制备、活流感病毒疫苗和个性化治疗性肿瘤疫苗等研究。牵头国家创新药物重大专项、科技部973项目、基金委创新群体、重点、重大和国际合作项目，在Science等杂志发表论文百余篇，其中活流感病毒疫苗研究入选国际疫苗学会“Paper of the Year”、中国科学十大进展及药明康德生命化学研究奖杰出成就奖等。
代表性学术成果：
1. Li H, Wang S, M W, Xiao S, LH Zhang, Zhou D*. Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders. J Med Chem. 2022, 65, 10, 7154–7169.
2. Zhang B, Wang Y, Sun J, Ji D, Yuan Y, Li S, Sun Y, Hou Y, Li P, Zhao L, Yu F, Ma W, Cheng B, Wu L, Hu J, Wang M, Chen H, Fei Y, Song W, Li X, Li H, Zhang L, Tsokos G, Zhou D*, Zhang X*. Precision PEGylation enables high-dose IL-2 to selectively activate Tregs and sustainably suppress autoimmune disease pathogenesis. Nature Biomed Eng. 2021, 5, 1288-1305.
3. Zhang B, Wang Y, Yuan Y, Sun J, Liu L, Huang D, Hu J, Wang M, Li S, Song W, Chen H, Zhou D*, Zhang X*. In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells. Ann. Rheum. Dis. 2021, 80 (2), 176-184.
4. Zhang B, Wang Y, Huang S, Sun J, Wang M, Ma W, You Y, Wu L, Hu J, Song W, Liu X, Li S, Chen H, Zhang G, Zhang L, Zhou D*, Li L*, Zhang X*. Photoswitchable CAR-T cell function in vitro and in vivo via a cleavable mediator. Cell Chem. Biol. 2021, 28 (1), 1-10.
5. Li H, Sun J, Xiao S*, Zhang L, Zhou D*. Triterpenoid-mediated inhibition of virus-host interaction: Is now the time for discovering viral entry/release inhibitors from nature? J. Med. Chem. 2020, 63 (24), 15371-15388.
6. Wang Y, Li S, Tian Z, Sun J, Liang S, Zhang B, Bai L, Zhang Y, Zhou X, Xiao S, Zhang Q, Zhang L, Zhang C*, Zhou D*. Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction. Nucleic Acids Res. 2019, 47(19), e114.
7. L Si, K Meng, Z Tian, J Sun, Z Zhang, H Li, G Fu, Q Xia, S Xiao, L Zhang, Zhou D*. Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes. Science Adv. 2018, 4: eaau8408.
8. Ling Wu, Jingxian Chen, Yiming Wu, Bo Zhang, Xiaochun Cai, Ziwei Zhang, Yan Wang, LongLong Si, Huan Xu, YongXiang Zheng, ChuanLing Zhang, Chenggang Liang, Jing Li, Lihe Zhang, Qiang Zhang, Demin Zhou*. Precise and combinatorial PEGylation generates a low-immunogenic, stable form of human growth hormone. J Control. Release. 2017, 249:84-93.
9. Longlong Si, Huan Xu, Xueying Zhou, Ziwei Zhang, Zhenyu Tian, Yan Wang, Yiming Wu, Bo Zhang, Zhenlan Niu, Chuanling Zhang, Ge Fu, Sulong Xiao, Qing Xia, Lihe Zhang, Demin Zhou*. Generation of Influenza A Viruses as Live but Replication-incompetent Virus Vaccines. Science. 2016, 354(6316):1170-1173.
10. Chuanling Zhang, Tianzhuo Yao, Yongxiang Zheng, Zhongjun Li, Lihe Zhang and Demin Zhou*. Development of Next Generation of Adeno-Associated Viral Vectors via Precision Engineering for Preferable Selective Tropism and Efficient Gene Delivery. Biomaterials. 2016, 80, 134-145.
