谢正伟，博士，博士生导师。北京大学-云南白药国际医学研究中心PI，衰老和AI制药研究专家。学术成果包括：1)开发了国际上第一款基于人工智能和基因指纹的药效预测系统——灵素系统；2）发现了减肥、降尿酸、治疗NASH的化合物；3）发现了延长寿命的系列分子和靶点机制；4）开发出第一代衰老微流芯片、发现了衰老标记蛋白HSP104和端粒酶失活的初始时期细胞即呈现早衰现象及其保护机制；5）发明了代谢网络中计算酶-流变化关系的的超立方收缩算法；6）发现小檗碱可以延长野生小鼠的寿命并揭示其分子机制；7）发现抑制乙酰转移酶Gcn5可以延长酵母和人细胞系的寿命。在Nature Biotechnology、Cell、Aging Cell等杂志发表论文。研究工作曾被《自然》杂志“新闻与视角”栏目长文报道，获评2016中国医学科学研究年度十大进展，2021中国生物信息年度十大进展， Faculty 1000多次推荐。主持合成生物学国家重点研发计划子课题一项，国家自然科学基金面上项目二项，北京市面上项目一项。任中国药理学会表观遗传分会委员，中国老年学和老年医学学会抗衰老分会委员。

代表性学术成果

1．Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou,*, Ning Zhang*, Ruimao Zheng*, Zhengwei Xie*. Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning. Nature biotechnology 2021,39:1444-1452. (doi: 10.1038/s41587-021-00946-z.) （2021年中国生物信息十大进展）

2．Weikaixin Kong#, Xinyu Tu#, Weiran Huang, Yang Yang, Zhengwei Xie*, Zhuo Huang*. Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing. J. Chem. Inf. Model May 18, 2020, 60（6）, 2739-2753 (doi:10.1021/acs.jcim.9b01180)

3．Yao Dang#, Yongpan An#, Jinzhao He, Boyue Huang, Jie Zhu, Miaomiao Gao, Shun Zhang, Xin Wang, Baoxue Yang* and Zhengwei Xie*. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020; 19:e13060

4．Boyue Huang#, Dandan Zhong#, Jie Zhu, Yongpan An, Miaomiao Gao, Shuai Zhu, Weiwei Dang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines. Aging Cell 2020; 00:e13129 (https://doi.org/10.l111/acel.13129)

5．Zhengwei Xie#*, Tianyu Zhang#, Qi Ouyang*, Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm, Bioinformatics, 2018.2.1, 34(3): 502~510

6．Zhengwei Xie#, Kyle Jay#, Dana L. Smith, Yi Zhang, Zairan Liu, Jiashun Zheng, Ruilin Tian, Hao Li*, and Elizabeth Blackburn*, Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length Cell, 2015, 160(5): 928-939

7．Zhengwei Xie, Yi Zhang, Ke Zou, Onn Brandman, Chunxiong Luo, Qi Ouyang*, Hao Li*, Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device, Aging Cell 2012, (11): 599~606