人才队伍
个人简介

乔雪,北京大学药学院、北京大学-云南白药国际医学研究中心研究员,博士生导师。北京大学博士,英国John Innes Centre访问学者。入选国家自然科学基金委优秀青年基金北京市杰出青年科学基金中国科协青年人才托举工程人才计划。

研究兴趣中药活性成分的生物合成组合合成、中药分析新方法、功能代谢组

J Am Chem SocAngew Chem Int EdPNASAnal Chem等期刊发表SCI论文90余篇,获专利10余项任天然产物传统期刊Fitoterapia杂志副主编J Pharm Anal期刊青年编委。兼任世界中医药学会联合会中药分析专业委员会副秘书长。


代表性学术成果

1Meng Zhang, Yang Yi, Baihan Gao, Hui-Fei Su, Yang-Oujie Bao, Xiao-Meng Shi, Hai-Dong Wang, Fu-Dong Li, Min Ye*, Xue Qiao*. Functional characterization and protein engineering of a triterpene 3-/6-/2′-O-glycosyltransferase reveal a conserved residue critical for the regiospecificity. Angew. Chem. Int. Ed. 2022, 61(8), e202113587.

2Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn*, Xue Qiao*. Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function. J. Adv. Res. 2022, doi.org/10.1016/j.jare.2022.03.014.

3Yang Zhang, Yuxi Huang, Jingjing Fan, Meng Zhang, Aobulikasimu Hasan, Yang Yi, Rong Yu, Xujie Zhou, Min Ye*, and Xue Qiao*. Expanding the scope of targeted metabolomics by one-pot microscale synthesis and tailored metabolite profiling: investigation of bile acid–amino acid conjugates. Anal. Chem. 2022, 94, 48, 16596-16603.

4Kuan Chen, Meng Zhang, Min Ye*, Xue Qiao*. Site-directed mutagenesis and substrate compatibility to reveal the structure-function relationships of plant oxidosqualene cyclases. Nat. Prod. Rep. 2021, 38, 2261-2275.

5Huifei Su, Sharpkate Shaker, Yi Kuang, Meng Zhang, Min Ye*, Xue Qiao*. Phytochemistry and cardiovascular protective effects of Huang-Qi (Astragali Radix). Med. Res. Rev. 2021, 41, 1999–2038.

6Meng Zhang#, Fu-Dong Li#, Kai Li#, Zi-Long Wang, Yu-Xi Wang, Jun-Bin He, Hui-Fei Su, Zhong-Yi Zhang, Chang-Biao Chi, Xiao-Meng Shi, Cai-Hong Yun, Zhi-Yong Zhang, Zhen-Ming Liu, Liang-Ren Zhang, Dong-Hui Yang, Ming Ma*, Xue Qiao*, Min Ye*. Functional characterization and structural basis of an efficient di-C-glycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc. 2020, 142, 3506-3512.

7Zi-Long Wang#, Hao-Meng Gao#, Shuang Wang, Meng Zhang, Kuan Chen, Ya-Qun Zhang, Hai-Dong Wang, Bo-Yun Han, Lu-Lu Xu, Tian-Qiao Song, Cai-Hong Yun, Xue Qiao*, Min Ye*. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc. Natl. Acad. Sci. U. S. A. 2020, 117(48), 30816-30823

8Jun-Bin He, Peng Zhao, Zhi-Min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-Hong Yun*, Xue Qiao*, Min Ye*. Molecular characterization and structural basis of a promiscuous C-glycosyltransferase from Trollius chinensis. Angew. Chem. Int. Ed. 2019, 58, 11513-11520.