北京大学国际癌症研究院、北京大学-云南白药国际医学研究中心、北京大学医学技术研究院、北京大学跨学部生物医学工程系研究员、博士生导师。主要从事生物材料与药物递送研究，在国际上率先提出了蛋白质-高分子精准偶联的概念，发展了定点原位聚合、类弹性蛋白多肽融合等新型蛋白质-高分子偶联技术，发明了仿生智能型蛋白质-高分子偶联物、抗体-高分子-药物偶联物、蛋白质-药物偶联物等新型生物偶联物，发现了乏氧触发氧化胺高分子生物还原、类弹性蛋白多肽嵌合体靶向降解蛋白等新现象，并揭示了其分子机制，为新型大分子药物和生物材料的设计、研发和临床转化提供了新思路。
在PNAS、JACS、Angew、AM等上发表了近60篇SCI论文。已有5项国内外发明专利转让于美国公司Gateway Biotech, Inc.和中山华梓生物科技有限公司，其中治疗恶性脑瘤的温敏干扰素即将申报临床一期。获Bayer Investigator Award、Janssen Investigator Award等奖励。主持或参与了6项国自然重大、重点和面上等科研项目，并任国自然、科技部 “十四五”及国家中长期科技发展战略规划编写组专家。
近期代表性文章
1．Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang, Weiping Gao*. Thermoresponsive polypeptide fused L-asparaginase with mitigated immunogenicity and enhanced efficacy in treating hematologic malignancies. Adv. Sci. 2023, 2300469.
2．Fei Duan, Wei Jin, Tong Zhang, Yuanzi Sun, Xuliang Deng*，Weiping Gao*,. Thermo-pH-sensitive polymer conjugated glucose oxidase for tumour-selective starvation-oxidation-immune therapy. Adv. Mater. 2023, adma.202209765
3．Longshuai Zhang, Jiawei Sun, Wenchao Huang, Sanke Zhang, Xuliang Deng, Weiping Gao*. Hypoxia-triggered bioreduction of poly(N-oxide)-drug conjugates enhances tumour penetration and antitumour efficacy. J. Am. Chem. Soc. 2023, 145, 1707−1713.
4．Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang*, Xuliang Deng*, Cyrille Boyer*, Weiping Gao*. N-Terminal Lysozyme Conjugation to a Cationic Polymer Enhances Antimicrobial Activity and Overcomes Antimicrobial Resistance. Nano Lett. 2022, 22, 8294−8303.
5．Like Gong, Zhaoying Yang, Fan Zhang, Weiping Gao*. Cytokine conjugates to elastin-like polypeptides. Adv. Drug Deliver. Rev. 2022, 190, 114541.
6．Xinyu Liu, Weiping Gao*. Precision conjugation: an emerging tool for generating protein‐polymer conjugates. Angew. Chem. Int. Ed. 2021, 60, 11024-11035.
7．Ping Liang, Guihuai Wang, Xinyu Liu, Zhuoran Wang, Jing Wang, Weiping Gao*. Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy. Biomaterials 2021, 264, 120447.
8．Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019, 6，1900586.
9．Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao*. Polymerization induced self-assembly of a site-specific interferon α-block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438.
10．Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324.
